Senior Bioinformatician - Mutographs of Cancer

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Salary Range: £31,498 to £39,729, plus excellent benefits. Fixed-Term contract for 5 years.

An exciting Statistical Software Developer opportunity has become available under the leadership of Professor Sir Mike Stratton as part of the CRUK Grand Challenge, Mutographs of Cancer project. Specifically, this position will involve helping to develop and apply novel statistical algorithms to unravel the mutational signatures that will explain the major global differences in cancer incidence. The project aims to understand the biological mechanisms underlying cancer-causing mutational processes and to explore their application towards surveillance of mutagenic exposures in human populations.

The successful candidate will be embedded in a multidisciplinary team and will be tasked with further developing the statistical analysis software and pipelines for this project. This role involves working at the interface between scientific and IT staff on this project to ensure efficient analysis of the large DNA sequencing data sets.

This position would suit a Bioinformatician/Software Developer with a strong statistical background who enjoys developing or enhancing software tools for the analysis of complex biological data sets. The analysis software needs to be efficient, visually appealing and interpretable by the scientific/clinical community. We are looking for an individual who enjoys working in a multi-disciplinary team environment to help solve complex IT issues which will ultimately aid our understanding of mutational processes in human cells.

Essential Skills

* Good degree in the areas of Bioinformatics, Mathematics, Physics or Computer Science with a scientific background.

* Experience of statistical analysis in bioinformatics (e.g. R and/or Julia)

* Software development skills (e.g. Perl and/or Python)

* Experience of handling Next Generation sequencing data

* LSF or Open Grid scheduling software

* Experience working, developing and compiling software tools in a UNIX/LINUX environment.

* Enjoy working as part of a team

Ideal Skills

* Software development using a compiled language (C,C++,Java)

* Experience of workflow management IT systems

* Experience of VMware, OpenStack or Amazon Web Services (AWS)

* ORACLE/MySQL databases

* Experience of working in an Agile Software Development Group

* Web development using Perl, Java, HTML(5), CSS, JavaScript

* Background in cancer genetics

Other information

The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease.

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Please include a covering letter and CV with your application.

Closing date for applications: 7th June 2017, however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.