Postdoctoral Fellow - Comparative Analysis of Cancer Genomes

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Salary £31,115 to £39,004 plus excellent benefits. Fixed term for 3 years.

We are seeking a Computational Biologist to join the Garnett team to lead the comparative genomic analysis of patient tumours and a new generation of tumour organoid models.

In collaboration with Cancer Research UK, we are deriving and characterising hundreds of new cancer organoid cell culture models as a resource for the community. These new cell models will be whole-genome DNA-sequenced, RNA-sequenced, and profiled for their sensitivity to anti-cancer drugs. This project is part of the Human Cancer Model Initiative (http://www.sanger.ac.uk/science/collaboration/human-cancer-model-initiative-hcmi).

We seek a talented Computational Biologist to drive forward the analysis of these large dataset. They will oversee the analyses of the genomic data, including comparative analyses with patient primary tissue, analyses of tumour heterogeneity, and integration with drug sensitivity data. The candidate will have access to exceptional sequencing and IT infrastructure at the Sanger Institute. As part of a multidisciplinary team, they will be tasked with contributing towards the development of algorithms and pipelines for this project and the team, as well as interpreting the output of complex data sets.

The ideal applicant will have a PhD in cancer biology, cancer bioinformatics, or a related discipline. Only applicants with demonstrated expertise in the analysis of large genomic datasets and ideally cancer genomic datasets will be considered. Experience with at least one scripting language would be a requirement.

Essential Skills

* Educated to PhD level in one of the following fields: bioinformatics, computational biology, cancer genomics, or computer science

* Advanced level programming skills suitable for integrating genomic and bioinformatics datasets and the ability to annotate genetic findings

* Previous experience working with next-generation sequencing data

* Ability to communicate ideas and results effectively

* Ability to work independently and organise own workload

* Experience with at least one scripting language

Ideal Skills

* Statistical skills (significance tests, statistical distributions, fitting of statistical models)

* Good publication record

Other information

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Please include a covering letter and CV with your application.

Closing date for applications: 8th June 2017, however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.