Senior Bioinformatician

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Salary Range: £31,498 to £39,729, plus excellent benefits. Fixed-Term contract until 31/01/2022

An exciting Software Analysis and Development opportunity has become available within the Cancer, Ageing and Somatic Mutation Group (CASM). The successful candidate will be embedded in a large multidisciplinary team and will be tasked with further developing our cancer analysis algorithms specifically for blood cancers.

The role involves working closely with scientific and IT staff within CASM to develop novel analytical strategies as well as actively contributing to the statistical modelling and data analysis of this study. In addition, the role will also involve improving existing algorithms to analyse whole genome sequencing and methylation data as well as developing new software where required.

The position would suit a Bioinformatician/Statistician who enjoys developing algorithms and building statistical models to analyse complex NGS biological datasets. We are looking for an individual who enjoys working in a multi-disciplinary team environment to help solve complex IT issues which will ultimately aid our analysis of cancer related datasets.

Essential Skills

* Good degree in Bioinformatics, Mathematics, Statistics or Computer Science with a scientific background

* Software development using a compiled language (C,C++, Java)

* Software development skills (using Perl and/or Python)

* Experience of statistical analysis in bioinformatics

* Experience of analysing biological data

* Extensive experience of communicating effectively internally at all levels and with select external individuals

* Able to present data

* Ability to work independently and organise own workload

* Previous scientific publications

* Enjoy working as part of a team

Ideal Skills

* PhD in a bioinformatics or mathematics subject

* ORACLE/MySQL databases

* LSF or Open Grid scheduling software

* Experience of workflow management IT systems

* Experience of VMware, OpenStack or Amazon Web Services (AWS)

* Experience working, developing and compiling software tools in a UNIX/LINUX environment.

* Background in cancer genetics

* Evidence of academic excellence

Other information

The CASM Group has led the way in the systematic analysis of cancer genomes by using the human genome sequence and high throughput mutation detection techniques to identify somatically acquired sequence variants/mutations and hence identify genes critical in the development of human cancers (http://www.sanger.ac.uk/genetics/CGP/).

The IT group has developed a suite of algorithms to analyse genetic variation in cancer genome data. This includes software to detect tumour genetic variation (e.g. single-base substitutions, structural rearrangements, copy number changes) and the ability to annotate the resulting variants and mine the data for interesting patterns and signatures.

Campus Life

The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited's 100,000 Genomes Sequencing Centre.

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays.

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Please include a covering letter and CV with your application.